Hydrochloric Acid → HCID 70032107, compound

HRID 2187494Notes

Reaction equation

HRID 2187494 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)=[C:8]2[C:3]=1[CH2:4][CH2:5][C@@H:6]([NH:19][C:20](=[O:33])[C:21]1[CH:26]=[CH:25][C:24]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[CH:23][CH:22]=1)[CH2:7]2.[ClH:34]>O1CCCC1.C(OCC)C>[ClH:34].[CH3:1][C:2]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)=[C:8]2[C:3]=1[CH2:4][CH2:5][C@@H:6]([NH:19][C:20](=[O:33])[C:21]1[CH:26]=[CH:25][C:24]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[CH:23][CH:22]=1)[CH2:7]2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 9846516AR-A000002

Product 1

HCID 70032107HCID 70032107, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent

Procedure

(R)-N-[5-Methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide (100 mg, 0.22 mmol) was dissolved in anhydrous tetrahydrofuran (15 mL) and HCl in anhydrous diethyl ether (4 M) was added dropwise until the solution was acidic. The white precipitate was filtered and washed with diethyl ether to give the title compound as white crystals.

Workup

  1. filtrationThe white precipitate was filtered
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-fa11ec04b3c6464280fa45530c533d25
Source dataset
uspto-grants-2002_06
Patent number
US06410532B1

Reaction notes

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