Potassium Carbonate → HCID 58280122, compound

HRID 2189029Notes

Reaction equation

HRID 2189029 reaction equation
Cl[C:2]1[C:3]2[C:10]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[C:9]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[O:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:25][C:26]1[CH:27]=[C:28]([OH:32])[CH:29]=[CH:30][CH:31]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:18][O:17][C:14]1[CH:15]=[CH:16][C:11]([C:10]2[C:3]3[C:2]([O:32][C:28]4[CH:27]=[C:26]([CH:31]=[CH:30][CH:29]=4)[NH2:25])=[N:7][CH:6]=[N:5][C:4]=3[O:8][C:9]=2[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 115683-AminophenolHCID 580168154-Chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine

Product 1

HCID 58280122HCID 58280122, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Stir 1000 mg (2.97 mmol) of 4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine, 1296 mg (11.9 mmol) of 3-aminophenol and 615.6 mg (4.45 mmol) of potassium carbonate in 10 ml of DMF at 80° C. for 8 h. After cooling, concentrate under reduced pressure and take up the residue in water. Filter off the precipitated solid, wash the filter residue repeatedly with water and dry the solid at 50° C. under high vacuum. 1195 mg (98.3% of theory) of the target compound are obtained as a brownish solid.

Workup

  1. temperatureAfter cooling
  2. concentrationconcentrate under reduced pressure
  3. filtrationFilter off the precipitated solid
  4. washwash the filter residue repeatedly with water
  5. customdry the solid at 50° C. under high vacuum
  6. custom1195 mg (98.3% of theory) of the target compound are obtained as a brownish solid

Sources & evidence

ORD record
ord-fea78a02a27d4eeeb30cc7302b291a00
Source dataset
uspto-grants-2012_12
Patent number
US08324222B2

Reaction notes

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