反应详情

温度

160 °C

In a microwave vial is added (2-Chloro-5-prop-1-ynyl-pyrimidin-4-yl)-(1-ethyl-propyl)-amine (0.22 g, 0.92 mmol), anhydrous DMF (3 ml), and CuI (53 mg, 0.27 mmol). The reaction is heated at 160° C. for 1 hr by employing microwave. The reaction mixture is diluted with EtOAc, washed with sat. NaHCO3 aqueous solution and water, dried over Na2SO4, and concentrated in vacuo. Purification with column chromatography (SiO2, 1:4 EtOAC/Hexane) gives 43 mg of the desired product.

1. washwashed with sat. NaHCO3 aqueous solution and water
2. dry with materialdried over Na2SO4
3. concentrationconcentrated in vacuo
4. customPurification with column chromatography (SiO2, 1:4 EtOAC/Hexane)