Hydrochloric Acid → HCID 178513242, compound

HRID 2189733Notes

Reaction equation

HRID 2189733 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]#[N:11])=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[NH2:12][OH:13].Cl.C([O-])(O)=O.[Na+]>CO>[OH:13][NH:12][C:10]([C:6]1[CH:5]=[C:4]2[C:9](=[CH:8][CH:7]=1)[NH:1][N:2]=[CH:3]2)=[NH:11]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 787HydroxylamineHCID 516892Sodium BicarbonateHCID 111263841H-Indazole-5-carbonitrile

Product 1

HCID 178513242HCID 178513242, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

5-cyano indazole (D1) (500 mg), hydroxylamine.HCl (485 mg) and NaHCO3 (1.47 g) were dissolved/suspended in MeOH (18 ml), heated to 50° C. and stirred for 19 hours and overnight. The reaction mixture was then filtered, washed with MeOH and evaporated to give the title compound (584 mg) as a white solid. MS (ES): C8H8N4O requires 176; found 177 (MH+).

Workup

  1. filtrationThe reaction mixture was then filtered
  2. washwashed with MeOH
  3. customevaporated

Sources & evidence

ORD record
ord-e511639655ae48a6b9fcc5f6e5f1524d
Source dataset
uspto-grants-2012_12
Patent number
US08324254B2

Reaction notes

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