反应详情

温度

50 °C

5-cyano indazole (D1) (500 mg), hydroxylamine.HCl (485 mg) and NaHCO3 (1.47 g) were dissolved/suspended in MeOH (18 ml), heated to 50° C. and stirred for 19 hours and overnight. The reaction mixture was then filtered, washed with MeOH and evaporated to give the title compound (584 mg) as a white solid. MS (ES): C8H8N4O requires 176; found 177 (MH+).

1. filtrationThe reaction mixture was then filtered
2. washwashed with MeOH
3. customevaporated