HRID2190197

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

HCID2760897

Cyclopropylboronic acid

C3H7BO2

结构：COc1cccc(OC)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1

HCID11269872

2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl

C26H35O2P

结构：CNC(=O)c1c(-c2ccc(C)cc2)oc2nc(N(CCCCBr)S(C)(=O)=O)c(I)cc12

HCID58052297

未命名化合物

PRODUCTS

生成物

结构：CNC(=O)c1c(-c2ccc(C)cc2)oc2nc(N(CCCCBr)S(C)(=O)=O)c(C3CC3)cc12

HCID54575876

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID167845

Diacetatopalladium

C4H6O4Pd

溶剂HCID1140

Toluene

C7H8

2 次

PROCEDURE

实验过程

To 6-(N-(4-bromobutyl)methylsulfonamido)-5-iodo-N-methyl-2-(p-tolyl)furo[2,3-b]pyridine-3-carboxamide (57 mg, 0.092 mmol) was added a premixed solution of S-Phos (3.77 mg, 9.19 μmol) and Pd(OAc)2 (0.825 mg, 3.68 μmol) in toluene (300 μL). Added a premixed solution of 2N SODIUM CARBONATE (919 μL, 1.838 mmol) and cyclopropylboronic acid (118 mg, 1.378 mmol) in toluene (900 μL). Degassed with N2 for 60 minutes.

WORKUP

后处理

customDegassed with N2 for 60 minutes

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-117224c4e05d4dd58baece7659908d82
来源数据集: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08324239B2
来源说明: uspto-grants-2012_12

反应 SMILES

[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]([C:11]1[N:16]=[C:15]2[O:17][C:18]([C:24]3[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][CH:25]=3)=[C:19]([C:20]([NH:22][CH3:23])=[O:21])[C:14]2=[CH:13][C:12]=1I)[S:7]([CH3:10])(=[O:9])=[O:8].CO[C:34]1C=CC=C(OC)[C:39]=1[C:40]1C=CC=CC=1P(C1CCCCC1)C1CCCCC1.C(=O)([O-])[O-].[Na+].[Na+].C1(B(O)O)CC1>C1(C)C=CC=CC=1.CC([O-])=O.CC([O-])=O.[Pd+2]>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]([C:11]1[N:16]=[C:15]2[O:17][C:18]([C:24]3[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][CH:25]=3)=[C:19]([C:20]([NH:22][CH3:23])=[O:21])[C:14]2=[CH:13][C:12]=1[CH:40]1[CH2:39][CH2:34]1)[S:7]([CH3:10])(=[O:9])=[O:8]