反应详情

233 mg (1.75 mmol) of N-chlorosuccinimide are added to a solution of 540 mg (1.59 mmol) of 2,2,2-trifluoro-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]acetamide in anhydrous tetrahydrofuran (20 ml). The solution is stirred overnight. 20 ml of a saturated sodium bicarbonate solution are added, and the mixture is extracted with ethyl acetate (two times 20 ml). The combined organic phases are washed with a saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. This gives a solid which is not purified any further.

1. extractionthe mixture is extracted with ethyl acetate (two times 20 ml)
2. washThe combined organic phases are washed with a saturated sodium chloride solution
3. dry with materialThe organic phase is dried over magnesium sulfate
4. concentrationconcentrated
5. customThis gives a solid which
6. customis not purified any further