反应详情

温度

100 °C

DMF (2 mL) was added to a mixture of 3-bromo-1-(2-(methylthio)pyrimidin-4-yl)-6-(3-nitrophenyl)-1H-indole (130 mg, 0.295 mmol), K3PO4 (188 mg, 0.885 mmol) and 4-methoxyphenylboronic acid (90 mg, 0.59 mmol) and then the dissolved gas was removed. After adding Pd(PPh3)4 (68 mg, 0.055 mmol), the mixture was stirred at 100° C. for 4 hours. After adding ethyl acetate and water and then filtering using a diatomite pad, the organic layer was separated and the aqueous layer was extracted with ethyl acetate. The collected organic layer was washed with brine and concentrated under reduced pressure by drying with anhydrous magnesium sulfate. The residue was purified by chromatography (silica gel, EA:Hx=1:4-1:1). The target compound (96 mg) was obtained as white solid.

1. customthe dissolved gas was removed
2. filtrationfiltering
3. customthe organic layer was separated
4. extractionthe aqueous layer was extracted with ethyl acetate
5. washThe collected organic layer was washed with brine
6. concentrationconcentrated under reduced pressure
7. dry with materialby drying with anhydrous magnesium sulfate
8. customThe residue was purified by chromatography (silica gel, EA:Hx=1:4-1:1)