Diisopropylethylamine → N-(3-(3-(4-methoxyphenyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-indol-6-yl)phenyl)-3-morpholino-5-(trifluoromethyl)benzamide

HRID 2192277Notes

Reaction equation

HRID 2192277 reaction equation
CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[O:25]1[CH2:30][CH2:29][N:28]([C:31]2[CH:32]=[C:33]([CH:37]=[C:38]([C:40]([F:43])([F:42])[F:41])[CH:39]=2)[C:34]([O-:36])=O)[CH2:27][CH2:26]1.[NH2:44][C:45]1[CH:46]=[C:47]([C:51]2[CH:59]=[C:58]3[C:54]([C:55]([C:68]4[CH:73]=[CH:72][C:71]([O:74][CH3:75])=[CH:70][CH:69]=4)=[CH:56][N:57]3[C:60]3[N:65]=[CH:64][N:63]=[C:62]([NH:66][CH3:67])[CH:61]=3)=[CH:53][CH:52]=2)[CH:48]=[CH:49][CH:50]=1.CCN(C(C)C)C(C)C.C(=O)(O)[O-].[Na+]>C1COCC1>[CH3:75][O:74][C:71]1[CH:70]=[CH:69][C:68]([C:55]2[C:54]3[C:58](=[CH:59][C:51]([C:47]4[CH:46]=[C:45]([NH:44][C:34](=[O:36])[C:33]5[CH:37]=[C:38]([C:40]([F:43])([F:42])[F:41])[CH:39]=[C:31]([N:28]6[CH2:27][CH2:26][O:25][CH2:30][CH2:29]6)[CH:32]=5)[CH:50]=[CH:49][CH:48]=4)=[CH:52][CH:53]=3)[N:57]([C:60]3[CH:61]=[C:62]([NH:66][CH3:67])[N:63]=[CH:64][N:65]=3)[CH:56]=2)=[CH:73][CH:72]=1

Participants

7

Reactant 5

HCID 81531DiisopropylethylamineHCID 516892Sodium BicarbonateHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 509920026-(6-(3-aminophenyl)-3-(4-methoxyphenyl)-1H-indol-1-yl)-N-methylpyrimidin-4-amineHCID 866513803-Morpholino-5-(trifluoromethyl)benzoate

Product 1

HCID 50992088N-(3-(3-(4-methoxyphenyl)-1-(6-(methylamino)pyrimidin-4-yl)-1H-indol-6-yl)phenyl)-3-morpholino-5-(trifluoromethyl)benzamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

HATU (100 mg, 0.260 mmol) was added to a mixture solution of 3-morpholino-5-(trifluoromethyl)benzoate (54 mg, 0.195 mmol), 6-(6-(3-aminophenyl)-3-(4-methoxyphenyl)-1H-indol-1-yl)-N-methylpyrimidin-4-amine (55 mg, 0.130 mmol) and DIPEA (45 μL, 0.26 mmol) in THF (2 mL) at room temperature. 12 hours later, the mixture was added to saturated sodium bicarbonate aqueous solution and then extracted with methylene chloride. The collected organic layer was washed with brine and then concentrated under reduced pressure by drying with anhydrous magnesium sulfate. The residue was purified by chromatography (preparative HPLC). The target compound was obtained as yellow solid.

Workup

  1. extractionextracted with methylene chloride
  2. washThe collected organic layer was washed with brine
  3. concentrationconcentrated under reduced pressure
  4. dry with materialby drying with anhydrous magnesium sulfate
  5. customThe residue was purified by chromatography (preparative HPLC)
  6. customThe target compound was obtained as yellow solid

Sources & evidence

ORD record
ord-54cb49254a1c4ccab06db7da91fc5c19
Source dataset
uspto-grants-2012_12
Patent number
US08329708B2

Reaction notes

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