Hydrochloric Acid → HCID 67028088, compound

HRID 2192300Notes

Reaction equation

HRID 2192300 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[N:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Br:15][CH2:16][C:17](Br)=[O:18].Cl>O.ClCCl>[Br:15][CH2:16][C:17]([NH:8][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([CH3:1])[N:7]=1)=[O:18]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 11430Potassium Carbonate2×HCID 61147Bromoacetyl bromide2×HCID 122369392-Amino-6-methylpyrazine

Product 1

HCID 67028088HCID 67028088, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent3×HCID 6344DichloromethaneSolvent

Procedure

6-Methyl-pyrazin-2-ylamine (150 mg) and potassium carbonate (571 mg) were added to dichloromethane (25 mL). 2-Bromoacetyl bromide (0.120 mL) was added to the suspension with stirring. The reaction was stirred overnight then water (0.1 mL) was added with further stirring. Further quantities of potassium carbonate (571 mg), 2-bromoacetyl bromide (0.120 mL) and water (0.1 mL) were added over 2 hours until the reaction had proceeded to completion. The reaction was diluted with water (100 mL), carefully acidified with hydrochloric acid and extracted with dichloromethane (2×50 mL) which was dried and evaporated to afford the sub-titled compound which was used crude (365 mg).

Workup

  1. stirringThe reaction was stirred overnight
  2. extractionextracted with dichloromethane (2×50 mL) which
  3. customwas dried
  4. customevaporated

Sources & evidence

ORD record
ord-5f3b1d0e63b64ca58432df4a82403ebc
Source dataset
uspto-grants-2012_12
Patent number
US08329729B2

Reaction notes

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