反应详情

2-[(Furan-2-ylmethyl)amino]-7,7-dimethyl-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxylic acid (390 mg), tert-butyl 3-[(2-methylpropyl)amino]piperidine-1-carboxylate (350 mg) and N,N-diisopropylethylamine (1.2 ml) were dissolved in 1,2-dichloroethane (10 ml), chloro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate (540 mg) was added and the mixture was stirred at room temperature for 18 hr. The reaction mixture was diluted with saturated aqueous sodium hydrogen carbonate solution and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography, and the fraction eluted with ethyl acetate-hexane (5:95-100:10) was concentrated under reduced pressure to give the object compound (123 mg).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe extract was washed with saturated brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was evaporated under reduced pressure
5. washthe fraction eluted with ethyl acetate-hexane (5:95-100:10)
6. concentrationwas concentrated under reduced pressure