反应详情

Methyl 2-cyano-3,3-bis(methylsulfanyl)prop-2-enoate (4.06 g) and 2,2-dimethylpropanamide (2.02 g) were dissolved in DMA (200 ml), and sodium hydride (1.92 g) was added under ice-cooling. The mixture was stirred at room temperature overnight, and poured into ice. The mixture was acidified with 1 N aqueous hydrochloric acid solution. The precipitated crystals were collected by filtration, and dried to give the object compound (2.4 g).

1. temperaturecooling
2. additionpoured into ice
3. filtrationThe precipitated crystals were collected by filtration
4. customdried