Hydrochloric Acid → HCID 66662781, compound

HRID 2193483Notes

Reaction equation

HRID 2193483 reaction equation
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([NH:18][C:19]([O:21][CH2:22][C:23]3[CH:28]=[C:27]([Cl:29])[CH:26]=[C:25]([Cl:30])[CH:24]=3)=[O:20])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>C(O)CC.CC(O)C.C(OCC)C>[Cl:29][C:27]1[CH:28]=[C:23]([CH:24]=[C:25]([Cl:30])[CH:26]=1)[CH2:22][O:21][C:19](=[O:20])[NH:18][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:17][CH2:16]2

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 66662355HCID 66662355, compound

Product 1

HCID 66662781HCID 66662781, compound

Reagents, catalysts & solvents 3

HCID 10311-PropanolSolventHCID 3283Diethyl EtherSolventHCID 3776IsopropanolSolvent

Procedure

Starting material 46 (170 mg, 0.4 mmol) was dissolved in 5 ml propanol. Then 1 ml HCl in 2-propanol (5-6 N) was added and the mixture was stirred over night at ambient temperature. The reaction mixture was then diluted with diethyl ether, concentrated in vacuo and stirred with diethyl ether, repeatedly decanting. Finally the solid residue was filtered off and dried in vacuo at 45° C. Thus the desired product 47 was isolated as brownish crystals (46 mg, 0.1 mmol, 35%).

Workup

  1. concentrationconcentrated in vacuo
  2. stirringstirred with diethyl ether
  3. customrepeatedly decanting
  4. filtrationFinally the solid residue was filtered off
  5. customdried in vacuo at 45° C

Sources & evidence

ORD record
ord-6856684df112426cacbecfb50f1e9b3f
Source dataset
uspto-grants-2012_12
Patent number
US08329907B2

Reaction notes

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