反应详情

温度

120 °C

The mixture of 5 g 2-nitro-5-chlorobenzoic acid and 15 ml 2,6-dimethylmorpholine is stirred at 120° C. for 6 hours. To the reaction mixture 150 ml of ethyl acetate is added. The precipitated yellow crystalline material is filtered off, dissolved in 15 ml water. The pH of the mixture is set to 6 with acetic acid. The precipitated material is filtered off, washed with water and dried, to obtain 4.2 g of the title compound (MH+:281).

1. filtrationThe precipitated yellow crystalline material is filtered off
2. dissolutiondissolved in 15 ml water
3. filtrationThe precipitated material is filtered off
4. washwashed with water
5. customdried