Hydrochloric Acid → HCID 86652069, compound

HRID 2196439Notes

Reaction equation

HRID 2196439 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]2[N:12]=[C:13]3[CH:18]=[CH:17][C:16]([C:19]4[CH:20]=[C:21]([CH2:25][OH:26])[CH:22]=[CH:23][CH:24]=4)=[CH:15][N:14]3[CH:27]=2)[CH:2]=1.[ClH:28]>ClCCl.CO.C(O)(C)C>[ClH:28].[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]2[N:12]=[C:13]3[CH:18]=[CH:17][C:16]([C:19]4[CH:20]=[C:21]([CH2:25][OH:26])[CH:22]=[CH:23][CH:24]=4)=[CH:15][N:14]3[CH:27]=2)[CH:2]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 44230454HCID 44230454, compound

Product 1

HCID 86652069HCID 86652069, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3776IsopropanolSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of 90 mg of [3-[(2-quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]phenyl]methanol in dichloromethane and methanol is passed through sintered glass and then 5.2 ml of a 0.1N solution of hydrochloric acid in isopropanol is added to the filtrate. A precipitate forms, and is collected by filtration and washed with diethyl ether. The solid is then dissolved at ambient temperature with the minimum amount of methanol and then taken up with diethyl ether. The precipitate is recovered by filtration and oven-dried under reduced pressure. 66 mg of compound are obtained.

Workup

  1. filtrationA precipitate forms, and is collected by filtration
  2. washwashed with diethyl ether
  3. dissolutionThe solid is then dissolved at ambient temperature with the minimum amount of methanol
  4. filtrationThe precipitate is recovered by filtration
  5. customoven-dried under reduced pressure

Sources & evidence

ORD record
ord-86cc53e16f5b44aa8486bd4bd0aabeed
Source dataset
uspto-grants-2012_12
Patent number
US08338451B2

Reaction notes

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