Hydrochloric Acid → HCID 44230599, compound

HRID 2196445Notes

Reaction equation

HRID 2196445 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:7]=[C:8]3[CH:13]=[CH:12][C:11]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=4[CH2:20][OH:21])=[CH:10][N:9]3[CH:22]=2)=[CH:2]1.[ClH:23]>ClCCl.C(O)(C)C>[ClH:23].[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:7]=[C:8]3[CH:13]=[CH:12][C:11]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=4[CH2:20][OH:21])=[CH:10][N:9]3[CH:22]=2)=[CH:2]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 44230600HCID 44230600, compound

Product 1

HCID 44230599HCID 44230599, compound

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 6344DichloromethaneSolvent

Procedure

156 mg of [2-(2-furan-3-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol are suspended in dichloromethane; 5.4 ml of a 0.1N solution of hydrochloric acid in isopropanol are added thereto, dropwise, and the mixture is stirred at ambient temperature. The reaction mixture is then concentrated under reduced pressure. The residual solid is taken up in diethyl ether and the precipitate is recovered by filtration, washed with diethyl ether and oven-dried under reduced pressure.

Workup

  1. concentrationThe reaction mixture is then concentrated under reduced pressure
  2. filtrationthe precipitate is recovered by filtration
  3. washwashed with diethyl ether
  4. customoven-dried under reduced pressure

Sources & evidence

ORD record
ord-6724f64f203c45e29d2169668de8875b
Source dataset
uspto-grants-2012_12
Patent number
US08338451B2

Reaction notes

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