Ammonium Hydroxide → HCID 178424774, compound

HRID 2197409Notes

Reaction equation

HRID 2197409 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[C:9]1[N:10]=[N:11][C:12]([O:15]C)=[CH:13][CH:14]=1.[OH-].[NH4+]>I.O>[CH3:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[C:3]=1[C:9]1[N:10]=[N:11][C:12]([OH:15])=[CH:13][CH:14]=1

Participants

5

Reactant 2

HCID 14923Ammonium HydroxideHCID 58326464HCID 58326464, compound

Product 1

HCID 178424774HCID 178424774, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 24841Hydrogen iodideSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 3-(2,6-dimethyl-phenyl)-6-methoxy-pyridazine (1.6 g, 7.47 mmol) in hydriodic acid (57% in water, 10 mL) is heated at 80° C. for 2.5 h. The cooled mixture is diluted with water, neutralized to pH 7 with ammonium hydroxide and extracted with EtOAc. The extract is washed with water, dried and concentrated to yield 6-(2,6-dimethyl-phenyl)-pyridazin-3-ol as a solid.

Workup

  1. extractionextracted with EtOAc
  2. washThe extract is washed with water
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-aa95a45b3f104eb599ab37d75149977a
Source dataset
uspto-grants-2012_12
Patent number
US08338591B2

Reaction notes

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