Sodium hydride → HCID 20517724, compound

HRID 2198871Notes

Reaction equation

HRID 2198871 reaction equation
F[C:2]1[CH:24]=[CH:23][CH:22]=[CH:21][C:3]=1[C:4]([N:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[OH:20])[CH:7]1[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][CH2:8]1)=[O:5].[H-].[Na+]>CN(C)C=O>[CH3:13][N:10]1[CH2:11][CH2:12][CH:7]([N:6]2[C:4](=[O:5])[C:3]3[CH:21]=[CH:22][CH:23]=[CH:24][C:2]=3[O:20][C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]2=3)[CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 24758Sodium hydrideHCID 20517720HCID 20517720, compound

Product 1

HCID 20517724HCID 20517724, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 5.3 g 2-fluoro-N-(2-hydroxyphenyl)-N-(1-methyl-piperidin-4-yl)benzamide, 1.1 g of a 55% sodium hydride/oil dispersion and 80 ml dimethylformamide are stirred at 80° for 18 hours. The reaction mixture is worked up as in Example 1(b) to give the heading compound, m.p. 173°-174.5°.

Workup

  1. customto give the heading compound, m.p. 173°-174.5°

Sources & evidence

ORD record
ord-f4f5702f876b400f96de93293bd74f38
Source dataset
uspto-grants-1982_11
Patent number
US04360525

Reaction notes

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