反应详情

温度

0 °C

Dissolve [3-nitro-5-(trifluoromethyl)phenyl]methanol (1.1 g, 5.18 mmol) and triethylamine (1.62 mL) in DCM (20 mL), cool to 0° C., add slowly p-toluenesulfonyl chloride (1.1 g, 6.02 mmol). After the addition, stir the reaction at room temperature for 15 hrs. TLC (EtOAc:PE=1:15) shows the reaction is complete. Concentrate under reduced pressure to get the crude product. Purification by chromatography (silica gel, EtOAc:PE=1:15) affords the title compound (655 mg, 55%).

1. additionAfter the addition
2. customthe reaction at room temperature for 15 hrs
3. concentrationConcentrate under reduced pressure
4. customto get the crude product
5. customPurification by chromatography (silica gel, EtOAc:PE=1:15)