Isopropanol → HCID 15284092, compound

HRID 22005Notes

Reaction equation

HRID 22005 reaction equation
[C:1]([CH:6]1[CH2:15][CH2:14][C:13]2[N:12]=[C:11]([Cl:16])[N:10]=[C:9](Cl)[C:8]=2[CH2:7]1)([O:3][CH2:4][CH3:5])=[O:2].CC(O)C.[OH-].[NH4+:23]>O>[NH2:23][C:9]1[C:8]2[CH2:7][CH:6]([C:1]([O:3][CH2:4][CH3:5])=[O:2])[CH2:15][CH2:14][C:13]=2[N:12]=[C:11]([Cl:16])[N:10]=1

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 14923Ammonium HydroxideHCID 15284091HCID 15284091, compound

Product 1

HCID 15284092HCID 15284092, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

A mixture of 6-Carboethoxy-2,4-dichloro-5,6,7,8-tetrahydroquinazoline (7.68 g), 2-propanol (7 mL) and 30% ammonium hydroxide (12 mL) was heated in a sealed tube at 130° C. for 20 min. The tube was cooled and 20 mL of H2O was added to the mixture. The solid which precipitated was collected and dried to yield 4-Amino-6-carboethoxy-2-chloro-5,6,7,8-tetrahydroquinazoline.

Workup

  1. temperatureThe tube was cooled
  2. customThe solid which precipitated
  3. customwas collected
  4. customdried

Sources & evidence

ORD record
ord-9b0014b90875450599bb8794904fd624
Source dataset
uspto-grants-1995_06
Patent number
US05426186

Reaction notes

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