Water → HCID 19367598, compound

HRID 22015Notes

Reaction equation

HRID 22015 reaction equation
[F-:1].[K+].C1OCCOCCOCCOCCOCCOC1.Cl[C:22]1[N:31]2[CH:32]=[C:33]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[F:41])[N:34]=[C:30]2[C:29]2[CH2:28][CH2:27][CH2:26][CH2:25][C:24]=2[N:23]=1.O>CN(C=O)C>[F:1][C:22]1[N:31]2[CH:32]=[C:33]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[F:41])[N:34]=[C:30]2[C:29]2[CH2:28][CH2:27][CH2:26][CH2:25][C:24]=2[N:23]=1

Participants

6

Reactant 4

HCID 962WaterHCID 2855718-Crown-6HCID 522689Potassium FluorideHCID 15284102HCID 15284102, compound

Product 1

HCID 19367598HCID 19367598, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 700 mg of potassium fluoride and 200 mg 18-crown-6 in 10 mL of DMF was added 5-Chloro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline (200 mg). This mixture was refluxed for 1.5 h, cooled to room temperature and poured into water. The aqueous solution was extracted with ethyl acetate, the organic layer was separated and dried, and the solvent removed m vacuo to yield 5-Fluoro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline (Compound 41), m.p. 154°-155° C.

Workup

  1. temperatureThis mixture was refluxed for 1.5 h
  2. extractionThe aqueous solution was extracted with ethyl acetate
  3. customthe organic layer was separated
  4. customdried
  5. customthe solvent removed m vacuo

Sources & evidence

ORD record
ord-f76a672437014b8a98a3d208210b6a7e
Source dataset
uspto-grants-1995_06
Patent number
US05426186

Reaction notes

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