反应详情

温度

50 °C

To a solution of (2,4-difluorophenyl)methyl 5-bromo-2-{[(2,4-difluorophenyl)methyl]oxy}-4-(4-morpholinylmethyl)benzoate (may be prepared as described in Description 21; 833 mg, 1.466 mmol) in tetrahydrofuran (4 ml) was added lithium hydroxide (211 mg, 8.79 mmol) and water (1 ml). The mixture was heated at 50° C. for 4 hours, cooled and neutralised with 2M hydrochloric acid (3.66 ml, 7.33 mmol). The solvent was removed in vacuo to yield the title compound as a white solid. 648 mg.

1. customThe solvent was removed in vacuo