1,2-Dichloroethane → HCID 56837194, compound

HRID 2204751Notes

Reaction equation

HRID 2204751 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:18]=[C:17]([C:19]([N:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)=[O:20])[C:16]([C:27]3[CH:28]=[N:29][N:30]([CH3:32])[CH:31]=3)=[CH:15][C:11]=2[C:12]([OH:14])=O)=[CH:4][CH:3]=1.C(N(C(C)C)CC)(C)C.[N:42]1[CH:47]=[CH:46][C:45]([NH2:48])=[CH:44][N:43]=1.ON1C2N=CC=CC=2N=N1.C(Cl)CCl>CN(C)C=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:18]=[C:17]([C:19]([N:21]3[CH2:22][CH2:23][O:24][CH2:25][CH2:26]3)=[O:20])[C:16]([C:27]3[CH:28]=[N:29][N:30]([CH3:32])[CH:31]=3)=[CH:15][C:11]=2[C:12]([NH:48][C:45]2[CH:46]=[CH:47][N:42]=[N:43][CH:44]=2)=[O:14])=[CH:4][CH:3]=1

Participants

7

Reactant 5

HCID 111,2-DichloroethaneHCID 81531DiisopropylethylamineHCID 181649HOAtHCID 2984924-AminopyridazineHCID 66611075HCID 66611075, compound

Product 1

HCID 56837194HCID 56837194, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 2-{[(4-fluorophenyl)methyl]oxy}-5-(1-methyl-1H-pyrazol-4-yl)-4-(4-morpholinylcarbonyl)benzoic acid (may be prepared as described in Description 29; 95 mg, 0.22 mmol) in N,N-dimethylformamide (3 ml) was added diisopropylethylamine (0.08 ml, 0.43 mmol), 4-pyridazinamine (24.67 mg, 0.26 mmol), 1-hydroxy-7-azabenzotriazole (35.3 mg, 0.26 mmol) and EDC (62.2 mg, 0.32 mmol). The mixture was stirred for 2 hours, the solvent removed in vacuo and the residue was purified by MDAP to yield the title compound as a white solid. 50 mg.

Workup

  1. customthe solvent removed in vacuo
  2. customthe residue was purified by MDAP

Sources & evidence

ORD record
ord-7fb4684fae2c457ebd268b3b5d606174
Source dataset
uspto-grants-2016_06
Patent number
US09365551B2

Reaction notes

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