反应详情

To a solution of 3-[(Z)-{[(6-aminopyridin-2-yl)methoxy]imino}(phenyl)methyl]-4-methyl-1,2,4-oxadiazol-5(4H)-one (600 mg, 1.84 mol, 1 eq) in isopropanol (8 mL) was added N,N-dimethylacetamide dimethyl acetal. The mixture was refluxed for 4 h30. Hydroxylamine hydrochloride (154 mg, 2.21 mmol, 1.2 eq) was added at room temperature and the mixture was stirred at room temperature for 2 days. The solvent was then evaporated and water was added. The resulting precipitate was filtered and dried under vacuum to afford N′-hydroxy-N-{6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}ethanimidamide (660 mg, 75% yield) as a white solid.

1. temperatureThe mixture was refluxed for 4 h30
2. customThe solvent was then evaporated
3. additionwater was added
4. filtrationThe resulting precipitate was filtered
5. customdried under vacuum