Triethylamine → HCID 88919651, compound

HRID 2206913Notes

Reaction equation

HRID 2206913 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2([C:27]([F:30])([F:29])[F:28])[CH2:14][CH2:13][N:12]([C:15]3[N:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[C:18]([CH2:25]N)=[CH:17][N:16]=3)[CH2:11]2)[CH:5]=[C:6]([Cl:9])[C:7]=1[Cl:8].C([N:33](CC)CC)C.[CH:38]1([C:41](Cl)=[O:42])[CH2:40][CH2:39]1>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2([C:27]([F:28])([F:29])[F:30])[CH2:14][CH2:13][N:12]([C:15]3[N:20]=[C:19]([C:21]([F:23])([F:24])[F:22])[C:18]([CH2:25][C:38]4([C:41]([NH2:33])=[O:42])[CH2:40][CH2:39]4)=[CH:17][N:16]=3)[CH2:11]2)[CH:5]=[C:6]([Cl:9])[C:7]=1[Cl:8]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 77637Cyclopropanecarbonyl chlorideHCID 594533771-{2-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanamine

Product 1

HCID 88919651HCID 88919651, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-{2-[3-(3,4,5-Trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanamine (0.15 g) and triethylamine (0.051 ml) were dissolved in methylene chloride (3 ml), and to the solution was added cyclopropane carbonyl chloride (0.033 ml, 0.37 mmol) at room temperature. The reaction mixture was stirred overnight and the solvent was distilled off under reduced pressure. The residue was purified by column chromatography to obtain the target compound (0.135 g).

Workup

  1. distillationthe solvent was distilled off under reduced pressure
  2. customThe residue was purified by column chromatography

Sources & evidence

ORD record
ord-3e000340de0a4848aba4dae35b6ddc9b
Source dataset
uspto-grants-2016_06
Patent number
US09375000B2

Reaction notes

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