Hydrochloric Acid → HCID 90100566, compound

HRID 2207303Notes

Reaction equation

HRID 2207303 reaction equation
C(OC(=O)[N:7]([S:13]([C:16]1[CH:21]=[CH:20][C:19](F)=[C:18]([F:23])[CH:17]=1)(=[O:15])=[O:14])[C:8]1[S:9][CH:10]=[CH:11][N:12]=1)(C)(C)C.C([Li])CCC.[C:30]1([C:36]2[N:43]=[CH:42][CH:41]=[CH:40][C:37]=2[CH:38]=[O:39])[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.Cl>O1CCCC1.O.C(OCC)(=O)C>[F:23][C:18]1[CH:17]=[C:16]([S:13]([NH:7][C:8]2[S:9][CH:10]=[CH:11][N:12]=2)(=[O:14])=[O:15])[CH:21]=[CH:20][C:19]=1[CH:38]([OH:39])[C:37]1[C:36]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)=[N:43][CH:42]=[CH:41][CH:40]=1

Participants

8

Reactant 4

HCID 313Hydrochloric AcidHCID 125818742-Phenylpyridine-3-carbaldehydeHCID 118522166HCID 118522166, compoundHCID 178418339Butyllithium

Product 1

HCID 90100566HCID 90100566, compoundYield 15.7%

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent2×HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
-78 °C

Procedure

100 mg (0.26 mmol) of tert-butyl((3,4-difluorophenyl)sulfonyl)(thiazol-2-yl)carbamate was dissolved in 5 mL of tetrahydrofuran under nitrogen gas, and cooled to −78° C. After adding 0.25 mL (0.39 mmol) of n-butyllithium (1.6 M in tetrahydrofuran) slowly, the mixture was stirred for 30 minutes as maintaining −78° C. 24.3 mg (0.13 mmol) of 2-phenylnicotinaldehyde was dissolved in 0.5 mL of tetrahydrofuran, and added to the above reacting solution. As warming from −78° C. to room temperature, the reacting solution was stirred for 24 hours. Ethyl acetate and water/1 N-hydrochloride were added to the reacting solution, and it was stirred. After separating layers, the organic layer only was collected and concentrated under reduced pressure. The obtained residue was separated by column chromatography (developing solvent, hexane:ethyl acetate=1:1) to obtain 9 mg (7.6% yield) of the title compound.

Workup

  1. temperatureas maintaining −78° C
  2. additionadded to the
  3. temperatureAs warming from −78° C. to room temperature
  4. stirringthe reacting solution was stirred for 24 hours
  5. stirringwas stirred
  6. customAfter separating layers
  7. customthe organic layer only was collected
  8. concentrationconcentrated under reduced pressure
  9. customThe obtained residue was separated by column chromatography (developing solvent, hexane:ethyl acetate=1:1)

Sources & evidence

ORD record
ord-57a0e2eb6c064604b0969c1d30e4f98c
Source dataset
uspto-grants-2016_06
Patent number
US09376429B2

Reaction notes

Loading…