Hydrochloric Acid → HCID 118431715, compound

HRID 2207979Notes

Reaction equation

HRID 2207979 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[C:16]([CH:20]3[N:24]([C:25]4[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=4[F:32])[N:23]=[C:22]([C:33]([F:39])([F:38])[C:34]([F:37])([F:36])[F:35])[CH2:21]3)[CH:17]=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[ClH:40]>C(OCC)(=O)C>[ClH:40].[N:11]1([C:14]2[CH:15]=[C:16]([CH:20]3[N:24]([C:25]4[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=4[F:32])[N:23]=[C:22]([C:33]([F:39])([F:38])[C:34]([F:35])([F:36])[F:37])[CH2:21]3)[CH:17]=[CH:18][CH:19]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118431894HCID 118431894, compound

Product 1

HCID 118431715HCID 118431715, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-[3-(4-BOC-piperazin-1-yl)-phenyl]-1-(2,4-difluoro-phenyl)-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole (760.0 mg, 1.6 mmol) prepared in Example 95 was added to a saturated solution of hydrochloric acid in ethyl acetate (10.0 mL). The reaction mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure to give 700.0 mg of the titled compound as a brown liquid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-7374941cfefa4d24839bb5651d96a20c
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

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