Hydrochloric Acid → HCID 118431697, compound

HRID 2207983Notes

Reaction equation

HRID 2207983 reaction equation
C([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:16]=[C:17]([CH:21]3[N:25]([C:26]4[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=4[F:33])[N:24]=[C:23]([C:34]([F:40])([F:39])[C:35]([F:38])([F:37])[F:36])[CH2:22]3)[CH:18]=[CH:19][CH:20]=2)[CH2:11][CH2:10]1)(OC(C)(C)C)=O.[ClH:41]>C(OCC)(=O)C>[ClH:41].[NH2:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:16]=[C:17]([CH:21]3[N:25]([C:26]4[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=4[F:33])[N:24]=[C:23]([C:34]([F:40])([F:39])[C:35]([F:38])([F:37])[F:36])[CH2:22]3)[CH:18]=[CH:19][CH:20]=2)[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118431622HCID 118431622, compound

Product 1

HCID 118431697HCID 118431697, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-{3-[4-(N-BOC-amino)-piperidin-1-yl]-phenyl}-1-(2,4-difluoro-phenyl)-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole (110.0 mg, 6.6 mmol) prepared in Example 98 was added to a saturated solution of hydrochloric acid in ethyl acetate (3.0 mL). The reaction mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure to give 100.0 mg of the titled compound as a brown liquid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-ceb765d36382434e8cde0b0d46552b9e
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

Loading…