Hydrochloric Acid → HCID 118432029, compound

HRID 2207993Notes

Reaction equation

HRID 2207993 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[C:16]([CH:20]3[N:24]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=4[Cl:31])[N:23]=[C:22]([C:32]([F:38])([F:37])[C:33]([F:36])([F:35])[F:34])[CH2:21]3)[CH:17]=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.Cl>C(OCC)(=O)C>[ClH:31].[Cl:31][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=1[N:24]1[CH:20]([C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[CH:15]=2)[CH2:21][C:22]([C:32]([F:38])([F:37])[C:33]([F:35])([F:36])[F:34])=[N:23]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118432034HCID 118432034, compound

Product 1

HCID 118432029HCID 118432029, compoundYield 223.9%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-[3-(4-BOC-piperazin-1-yl)-phenyl]-1-(2-chloro-phenyl)-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole (600.0 mg, 1.1 mmol) prepared in Example 119 was added to a saturated solution of hydrochloric acid in ethyl acetate (5.0 mL). The reaction mixture was stirred at room temperature for 3 hours and then concentrated under reduced pressure to give 610.0 mg of the titled compound as a brown liquid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-d2f11e9c5a8648dfb90b4f5300b8ffc6
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

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