Hydrochloric Acid → HCID 118432053, compound

HRID 2208002Notes

Reaction equation

HRID 2208002 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH:13]([C:14]2[CH:19]=[C:18]([C:20]3[CH2:21][CH2:22][N:23](C(OC(C)(C)C)=O)[CH2:24][CH:25]=3)[CH:17]=[CH:16][C:15]=2[F:33])[CH2:12][C:11]([C:34]([F:40])([F:39])[C:35]([F:38])([F:37])[F:36])=[N:10]1.[ClH:41]>C(OCC)(=O)C>[ClH:41].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH:13]([C:14]2[CH:19]=[C:18]([C:20]3[CH2:21][CH2:22][NH:23][CH2:24][CH:25]=3)[CH:17]=[CH:16][C:15]=2[F:33])[CH2:12][C:11]([C:34]([F:39])([F:40])[C:35]([F:37])([F:36])[F:38])=[N:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118431733HCID 118431733, compound

Product 1

HCID 118432053HCID 118432053, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-(2,4-Difluoro-phenyl)-5-[2-fluoro-5-(1-BOC-1,2,3,6-tetrahydropyridin-4-yl)-phenyl]-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole (360.0 mg, 0.70 mmol) prepared in Example 147 was added to a saturated solution of hydrochloric acid in ethyl acetate (5.0 mL). The reaction mixture was stirred at room temperature for 3 hours and then concentrated under reduced pressure to give 360.0 mg of the titled compound as a brown liquid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-9b62570f6bc54043ab95750c5fc67343
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

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