Hydrochloric Acid → HCID 118432130, compound

HRID 2208037Notes

Reaction equation

HRID 2208037 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[N:13]([C:14]2[CH:15]=[C:16]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([S:26]([CH2:29][CH2:30][CH2:31][N:32](C(OC(C)(C)C)=O)[CH3:33])(=[O:28])=[O:27])[CH:21]=3)[CH:17]=[CH:18][CH:19]=2)[N:12]=[C:11]([C:41]([F:47])([F:46])[C:42]([F:45])([F:44])[F:43])[CH2:10]1.[ClH:48]>C(OCC)(=O)C>[ClH:48].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[N:13]([C:14]2[CH:15]=[C:16]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([S:26]([CH2:29][CH2:30][CH2:31][NH:32][CH3:33])(=[O:28])=[O:27])[CH:21]=3)[CH:17]=[CH:18][CH:19]=2)[N:12]=[C:11]([C:41]([F:46])([F:47])[C:42]([F:45])([F:43])[F:44])[CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118431645HCID 118431645, compound

Product 1

HCID 118432130HCID 118432130, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-(2,4-Difluoro-phenyl)-1-{3′-[3-(N-BOC-N-methyl-amino)-propane-1-sulfonyl]-biphenyl-3-yl}-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole (10.0 mg, 0.01 mmol) prepared in Example 211 was added to a saturated solution of hydrochloric acid in ethyl acetate (1.0 mL). The reaction mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure to give 5.0 mg of the titled compound as a brown liquid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-63a91ff464134c6282c9001a27425ff1
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

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