Hydrochloric Acid → HCID 118431747, compound

HRID 2208091Notes

Reaction equation

HRID 2208091 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH:13]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:26][CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]3)=[CH:16][CH:15]=2)[CH2:12][C:11]([C:34]([C:40]([F:43])([F:42])[F:41])([C:36]([F:39])([F:38])[F:37])[OH:35])=[N:10]1.[ClH:44]>C(OCC)(=O)C>[ClH:44].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH:13]([C:14]2[CH:15]=[CH:16][C:17]([N:20]3[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)=[CH:18][CH:19]=2)[CH2:12][C:11]([C:34]([C:40]([F:41])([F:42])[F:43])([C:36]([F:38])([F:37])[F:39])[OH:35])=[N:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118431849HCID 118431849, compound

Product 1

HCID 118431747HCID 118431747, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-(2,4-Difluoro-phenyl)-5-[4-(4-BOC-homopiperazin-1-yl)-phenyl]-3-[di-(trifluoromethyl)-hydroxy-methyl]-4,5-dihydro-1H-pyrazole (340.0 mg, 0.6 mmol) prepared in Example 408 was added to a saturated solution of hydrochloric acid in ethyl acetate (5.0 mL). The reaction mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure to give 250.0 mg of the titled compound as a pale yellow solid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-dbae730d65464f3e85714d0ace7ba1e9
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

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