Hydrochloric Acid → HCID 118431633, compound

HRID 2208096Notes

Reaction equation

HRID 2208096 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH:12]([C:13]2[S:14][C:15]([C:18]3[CH2:19][CH2:20][N:21](C(OC(C)(C)C)=O)[CH2:22][CH:23]=3)=[CH:16][CH:17]=2)[CH2:11][C:10]([C:31]([C:37]([F:40])([F:39])[F:38])([C:33]([F:36])([F:35])[F:34])[OH:32])=[N:9]1.Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH:12]([C:13]2[S:14][C:15]([C:18]3[CH2:19][CH2:20][NH:21][CH2:22][CH:23]=3)=[CH:16][CH:17]=2)[CH2:11][C:10]([C:31]([C:33]([F:35])([F:34])[F:36])([C:37]([F:40])([F:38])[F:39])[OH:32])=[N:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118431705HCID 118431705, compound

Product 1

HCID 118431633HCID 118431633, compoundYield 222.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-(2-Chloro-phenyl)-5-[5-(1-BOC-1,2,3,6-tetrahydropyridin-4-yl)-thiophen-2-yl]-3-[di-(trifluoromethyl)-hydroxy-methyl]-4,5-dihydro-1H-pyrazole (590.0 mg, 0.97 mmol) prepared in Example 416 was added to a saturated solution of hydrochloric acid in ethyl acetate (2.0 mL). The reaction mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure to give 590.0 mg of the titled compound as a yellow liquid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-ad8d77249a884603902e94eda114f39e
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

Loading…