反应详情

温度

90 °C

To a stirred solution of methyl 3-bromo-5-nitrobenzoate (17 g, 62.04 mmol) in ethanol (85 mL), was added NH4Cl solution (17 g in 85 mL water, 317.8 mmol) followed by Fe powder (27.82 g, 498.12 mmol). Resulting reaction mass was stirred at 90° C. for 1 h. On completion, reaction mass was filtered and filtrate concentrated till dryness to get solid which was dissolved in sat. sodium bicarbonate solution. Aqueous layer was extracted with ethyl acetate (3×50 mL). Combined organic layers were dried over sodium sulfate and concentrated to afford the desired compound (15 g, 99.14%).

1. customResulting
2. customreaction mass
3. customOn completion, reaction mass
4. filtrationwas filtered
5. concentrationfiltrate concentrated till dryness
6. customto get solid which
7. extractionAqueous layer was extracted with ethyl acetate (3×50 mL)
8. dry with materialCombined organic layers were dried over sodium sulfate
9. concentrationconcentrated