Hydrochloric Acid → HCID 51704107, compound

HRID 2209452Notes

Reaction equation

HRID 2209452 reaction equation
[CH2:1]([N:3](C(OC(C)(C)C)=O)[C@H:4]([CH3:9])[CH2:5][C:6]([OH:8])=[O:7])[CH3:2].Cl>C(OCC)(=O)C>[CH2:1]([NH:3][C@H:4]([CH3:9])[CH2:5][C:6]([OH:8])=[O:7])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86747529HCID 86747529, compound

Product 1

HCID 51704107HCID 51704107, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mechanically stirred solution of 53 (2.2 g, 9.7 mmol) in ethyl acetate (180 mL) at -15° C. was vigorously bubbled HCl gas for 30 min. The cooling bath (ethanol/ice) was removed and the solution purged with argon for 1.0 h to remove excess HCl. Concentration furnished the amine.HCl 54 as a yellow oil.

Workup

  1. customat -15° C.
  2. customfor 30 min
  3. customThe cooling bath (ethanol/ice) was removed
  4. customthe solution purged with argon for 1.0 h
  5. customto remove excess HCl
  6. concentrationConcentration

Sources & evidence

ORD record
ord-64751ef205ce4f4f919fe9bdb3a48749
Source dataset
uspto-grants-1995_10
Patent number
US05455243

Reaction notes

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