2-(Isopropylamino)ethanol → HCID 178457051, compound

HRID 2209817Notes

Reaction equation

HRID 2209817 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([C:6]([N:8]([C@H:10]2[CH2:15][CH2:14][C@H:13]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22]Cl)=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)[CH3:9])=[O:7])=[CH:4][CH:3]=1.[C:26](=[O:29])([O-])[O-].[K+].[K+].[CH:32]([NH:35][CH2:36]CO)([CH3:34])[CH3:33]>CN(C)C=O>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([C:6]([N:8]([C@H:10]2[CH2:11][CH2:12][C@H:13]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:26][OH:29])=[CH:18][C:17]=3[CH2:36][NH:35][CH:32]([CH3:34])[CH3:33])[CH2:14][CH2:15]2)[CH3:9])=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 79942-(Isopropylamino)ethanolHCID 11430Potassium CarbonateHCID 178485424HCID 178485424, compound

Product 1

HCID 178457051HCID 178457051, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

380 mg (1 mMol) of trans-N-(4-chlorobenzoyl)-N-methyl-4-(4-chloromethylphenyl)cyclohexylamine are reacted with 280 mg (2 mMol) of potassium carbonate and 110 mg (1.07 mMol) of 2-isopropylaminoethanol in 3 ml of dimethylformamide as described in Example 1. 259 mg (58.5% of theory) of the title compound are obtained in the form of colourless crystals, melting point 98°-100° C.

Sources & evidence

ORD record
ord-d4aaa9bb5799476e80ee3104db1d17b3
Source dataset
uspto-grants-1995_10
Patent number
US05455273

Reaction notes

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