Dabco → HCID 19379775, compound

HRID 2209990Notes

Reaction equation

HRID 2209990 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][CH:10]=[C:11](F)[CH:12]=3)[C:7](=[O:15])[C:6]([C:16]([OH:18])=[O:17])=[CH:5]2)[CH2:3][CH2:2]1.[CH:19]12[CH2:27][NH:26][CH2:25][CH:24]1[CH2:23][CH2:22][CH2:21][NH:20]2.N12CCN(CC1)CC2>CN1CCCC1=O>[CH:19]12[CH2:27][N:26]([C:11]3[CH:12]=[C:13]4[C:8]([C:7](=[O:15])[C:6]([C:16]([OH:18])=[O:17])=[CH:5][N:4]4[CH:1]4[CH2:3][CH2:2]4)=[CH:9][CH:10]=3)[CH2:25][CH:24]1[CH2:23][CH2:22][CH2:21][NH:20]2

Participants

5

Reactant 3

HCID 9237DabcoHCID 5154241Octahydro-1H-pyrrolo[3,4-b]pyridineHCID 98597081-Cyclopropyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Product 1

HCID 19379775HCID 19379775, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

741 mg (3 mmol) of 1-cyclopropyl-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid together with 567 mg (4.5 mol) of 2,8-diazabicyclo[4.3.0]nonane and 672 mg of 1,4-diazabicyclo[2.2.2]octane are heated for two hours at 100° C. in 30 ml of N-methylpyrrolidone. The mixture is concentrated under a high vacuum, and the residue is stirred thoroughly with acetonitrile and dried at 100° C.

Workup

  1. concentrationThe mixture is concentrated under a high vacuum
  2. customdried at 100° C.

Sources & evidence

ORD record
ord-8342d5de3d1e4151afe42e3b4fe82b20
Source dataset
uspto-grants-1995_10
Patent number
US05457104

Reaction notes

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