Acetic Acid → HCID 14585262, compound

4.15 g (32.4 mmol) of 1,6-anhydro-3,4-dideoxy-β-D-threo-hex-3-enopyranose, 17.20 g (65.6 mmol) of triphenyl phosphine, and 3.94 g (65.6 mmol) of acetic acid were added to 30 ml of dry THF, and a solution obtained by dissolving 11.42 g (65.6 mmol) of diethylazodicarboxylate in 50 ml of dry THF was gradually dropped in the above mixture in a nitrogen-sealed ice-water bath. The resultant solution was stirred at room temperature for 24 hours. The reaction solution was neutralized with a 1% aqueous sodium hydrogencarbonate solution in the ice-water bath, and the THF was distilled at a reduced pressure. The residue was extracted using diethyl ether. The extract was dried with magnesium sulfate, and the diethyl ether was distilled at a reduced pressure. Triphenyl phosphine oxide as a byproduct was eliminated from the residue using a silica gel column (eluent: chloroform). The solvent was distilled from the resultant eluate at a reduced pressure, and the residue was purified using a silica gel column (hexane:ethyl acetate=5:1 to 3:1). The purified residue was distilled at a reduced pressure (2 mmHg) to obtain 2.82 g (yield: 51.2%) of 2-O-acetyl-1,6-anhydro-3,4-dideoxy-β-D-erythro-hex-3-enopyranose.

1. customa solution obtained
2. additionwas gradually dropped in the above mixture in a nitrogen-
3. customsealed ice-water bath
4. distillationthe THF was distilled at a reduced pressure
5. extractionThe residue was extracted
6. dry with materialThe extract was dried with magnesium sulfate
7. distillationthe diethyl ether was distilled at a reduced pressure
8. distillationThe solvent was distilled from the resultant eluate at a reduced pressure
9. customthe residue was purified
10. distillationThe purified residue was distilled at a reduced pressure (2 mmHg)

ORD record

ord-bb502c53e7484bcda6f3a76c1d890cc6

Source dataset

uspto-grants-1995_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05457192