Methane → N-[2-(4-Carboxymethoxyphenyl)-1-methylethyl]-2-(2-amino-thiazol-4-yl)morpholine dichloride

HRID 2210390Notes

Reaction equation

HRID 2210390 reaction equation
[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([N:16]2[CH2:21][CH2:20][O:19][CH:18]([C:22]3[N:23]=[C:24]([NH:27]C(C)=O)[S:25][CH:26]=3)[CH2:17]2)[CH3:15])=[CH:9][CH:8]=1)([O:3]C)=[O:2].[ClH:31].C>>[Cl-:31].[Cl-:31].[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([N:16]2[CH2:21][CH2:20][O:19][CH:18]([C:22]3[N:23]=[C:24]([NH2:27])[S:25][CH:26]=3)[CH2:17]2)[CH3:15])=[CH:9][CH:8]=1)([OH:3])=[O:2]

Participants

4

Reactant 3

HCID 297MethaneHCID 313Hydrochloric AcidHCID 19974192N-[2-(4-carbomethoxymethoxyphenyl)1-methylethyl]-2-(2-acetamino-thiazol-4-yl)morpholine

Product 1

HCID 19974372N-[2-(4-Carboxymethoxyphenyl)-1-methylethyl]-2-(2-amino-thiazol-4-yl)morpholine dichloride

Procedure

1.6 g (0.0037 mol) of N-[2-(4-carbomethoxymethoxyphenyl)1-methylethyl]-2-(2-acetamino-thiazol-4-yl)morpholine in 100 ml of 18% strength hydrochloric acid are heated to reflux under nitrogen for 48 hours. 1.5 g of active charcoal are added to the reaction solution which is thoroughly stirred and filtered. The solution is then concentrated, and the product is dried in vacuo over potassium hydroxide.

Workup

  1. temperatureto reflux under nitrogen for 48 hours
  2. filtrationfiltered
  3. concentrationThe solution is then concentrated
  4. dry with materialthe product is dried in vacuo over potassium hydroxide

Sources & evidence

ORD record
ord-daf61896e31347b882530774ab25d460
Source dataset
uspto-grants-1995_10
Patent number
US05457205

Reaction notes

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