HCID 10563902, compound → HCID 9992351, compound

HRID 2210448Notes

Reaction equation

HRID 2210448 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[S:8]([NH:11][C:12]([CH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)=O)(=[O:10])=[O:9]>CN(C=O)C.P(Cl)(Cl)(Cl)=O>[CH:14]1([C:12]2[NH:1][C:2]3[CH:7]=[CH:6][N:5]=[CH:4][C:3]=3[S:8](=[O:10])(=[O:9])[N:11]=2)[CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

4

Reactant 1

HCID 10563902HCID 10563902, compound

Product 1

HCID 9992351HCID 9992351, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 24813Phosphorus oxychlorideSolvent

Procedure

A solution of 1 g of 4-amino-3-cyclopentylcarbonylaminosulfonylpyridine (Preparation 17) in 1 cm3 of DMF and 10 cm3 of phosphorus oxychloride is stirred at ambient temperature for 3 hours. The solvents are removed under partial vacuum (rotary evaporator) and the residue is dissolved in 10 cm3 of water. The solution is adjusted to a pH of 4 (NaHCO3) and the crystalline precipitate obtained is collected on a filter, washed with water and dried.

Workup

  1. customThe solvents are removed under partial vacuum (rotary evaporator)
  2. dissolutionthe residue is dissolved in 10 cm3 of water
  3. customthe crystalline precipitate obtained
  4. customis collected on a filter
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-0e3365d861e146e4afc61a5e07c584dc
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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