Methane → HCID 53917812, compound

HRID 2210450Notes

Reaction equation

HRID 2210450 reaction equation
[NH2:1][C:2]1[C:7]([S:8]([NH:11][C:12](=O)[CH3:13])(=[O:10])=[O:9])=[CH:6][N:5]=[C:4]([Cl:15])[CH:3]=1.C>C([O-])(O)=O.[Na+]>[Cl:15][C:4]1[N:5]=[CH:6][C:7]2[S:8](=[O:10])(=[O:9])[N:11]=[C:12]([CH3:13])[NH:1][C:2]=2[CH:3]=1

Participants

4

Reactant 2

HCID 297MethaneHCID 19378726HCID 19378726, compound

Product 1

HCID 53917812HCID 53917812, compound

Reagents, catalysts & solvents 1

HCID 516892Sodium BicarbonateSolvent

Procedure

0.2 g of 4-amino-5-acetylaminosulfonyl-2- chloropyridine (Preparation 19) is introduced into an open round-bottomed flask placed on an oil bath at 240° C. The temperature of the oil bath is brought over a period of a half-hour from 240° C. to 270° C. The molten mass is then cooled. It is dissolved in 4 cm3 of a tepid NaHCO3 solution (2% m/v). The solution is decolored with absorbing charcoal, filtered and then adjusted to a pH of 4 using formic acid. The crystalline precipitate obtained is collected on a filter, washed with water and dried.

Workup

  1. customplaced on an oil bath at 240° C
  2. waitThe temperature of the oil bath is brought over a period of a half-hour from 240° C. to 270° C
  3. temperatureThe molten mass is then cooled
  4. filtrationfiltered
  5. customThe crystalline precipitate obtained
  6. customis collected on a filter
  7. washwashed with water
  8. customdried

Sources & evidence

ORD record
ord-1994bc7f46bd4377bdf94a2097e5613a
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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