Methane → HCID 19378735, compound

HRID 2210452Notes

Reaction equation

HRID 2210452 reaction equation
[NH2:1][C:2]1[C:3]([S:8]([NH2:11])(=[O:10])=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1.N[C:13](N)=[O:14].C.Cl>[OH-].[Na+]>[O:14]=[C:13]1[NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[N:4][C:3]=2[S:8](=[O:10])(=[O:9])[NH:11]1

Participants

6

Reactant 4

HCID 297MethaneHCID 313Hydrochloric AcidHCID 1176UreaHCID 149437023-Aminopyridine-2-sulfonamide

Product 1

HCID 19378735HCID 19378735, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

An intimate mixture of 5 g of 3-aminopyridine-2- sulfonamide (Preparation 1) and 1.91 g of urea is progressively brought to a temperature of 200° C. (melting). After gas has ceased to be given off and the mass has solidified, the reaction mixture is cooled to ambient temperature. The solid mass is redissolved in 1N NaOH and the solution obtained, optionally decolored with absorbing charcoal, is then adjusted to a pH of 2 using 1N HCl. The white precipitate corresponding to the title compound is collected on a filter, washed with water and dried.

Workup

  1. customis progressively brought to a temperature of 200° C. (melting)
  2. customthe solution obtained
  3. customThe white precipitate corresponding to the title compound is collected on a filter
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-1e5e6e2f75c2476c85a16e189b10bea0
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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