Hydrochloric Acid → HCID 10512760, compound

HRID 2210456Notes

Reaction equation

HRID 2210456 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[CH:12](=O)[CH2:13][CH3:14].C(O)(C)C.Cl>C(OCC)(=O)C>[CH2:13]([CH:14]1[NH:1][C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[S:8](=[O:10])(=[O:9])[NH:11]1)[CH3:12]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 527PropanalHCID 3776IsopropanolHCID 109759664-Amino-3-pyridinesulfonamide

Product 1

HCID 10512760HCID 10512760, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

0.5 g of 4-aminopyridine-3-sulfonamide (Preparation 2) and 0.34 g (2 equivalents) of propionaldehyde are introduced into 5 cm3 of isopropanol to which 10 drops of a saturated solution of hydrochloric acid in ethyl acetate have been added. After refluxing for 2 h, the solution obtained is concentrated to dryness and the residue is recrystallized from a 1/3 isopropanol/petroleum ether (40°-60° C.) mixture.

Workup

  1. additionhave been added
  2. temperatureAfter refluxing for 2 h
  3. customthe solution obtained
  4. concentrationis concentrated to dryness
  5. customthe residue is recrystallized from a 1/3 isopropanol/petroleum ether (40°-60° C.) mixture

Sources & evidence

ORD record
ord-3a1a87344aac4471bdf2a81f5037c5cb
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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