Hydrochloric Acid → HCID 22419906, compound

HRID 2210534Notes

Reaction equation

HRID 2210534 reaction equation
[OH:1][N:2]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[N:17]=[C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[S:19][CH:20]=2)=[CH:10][CH:9]=1)[C:3](=[O:6])[NH:4][NH2:5].[ClH:27].C(OCC)C>C1COCC1>[ClH:27].[OH:1][N:2]([CH2:7][C:8]1[CH:9]=[CH:10][C:11]([O:14][CH2:15][C:16]2[N:17]=[C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[S:19][CH:20]=2)=[CH:12][CH:13]=1)[C:3](=[O:6])[NH:4][NH2:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl Ether2×HCID 15280390HCID 15280390, compound

Product 1

HCID 22419906HCID 22419906, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In to a solution of 4-hydroxy-4-[4-(2-phenyl-thiazol-4-ylmethoxy)-benzyl]-semicarbazide (1.0 g, 2.7 mmol) in THF (10 mL) was added 1N HCl in ethyl ether (1.0M, 2.7 mL, 27 mmol). After stirring for 10 minutes, additional ethyl ether (10 mL) was added and the precipitated solid was filtered and dried to give a white solid, in 88% yield, m.p. 159°-160° C.

Workup

  1. filtrationthe precipitated solid was filtered
  2. customdried
  3. customto give a white solid

Sources & evidence

ORD record
ord-8037f1baaa2c46a7803a28c9185c72d6
Source dataset
uspto-grants-1995_10
Patent number
US05459154

Reaction notes

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