Lithium Hydroxide → HCID 19379070, compound

HRID 2210552Notes

Reaction equation

HRID 2210552 reaction equation
C[O:2][C:3](=[O:27])[CH2:4][C:5]([N:7]1[CH2:12][CH2:11][CH:10]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)[CH:14]=2)[CH2:9][CH2:8]1)=[O:6].[OH-].[Li+]>C1COCC1>[CH:22]1([O:21][C:15]2[CH:14]=[C:13]([CH:10]3[CH2:9][CH2:8][N:7]([C:5](=[O:6])[CH2:4][C:3]([OH:27])=[O:2])[CH2:12][CH2:11]3)[CH:18]=[CH:17][C:16]=2[O:19][CH3:20])[CH2:23][CH2:24][CH2:25][CH2:26]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 54276370HCID 54276370, compound

Product 1

HCID 19379070HCID 19379070, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the same manner as Example, 8, 3-[4-(3-cyclopentyloxy-4-methoxyphenyl)piperidin-1-yl]-3-oxo-propionic acid methyl ester (6.7 mmol, 2.5 g), aqueous lithium hydroxide (1.0M; 8.4 mmol, 8.4 mL) in THF (70 mL) afforded the title compound as an off-white solid, mp=122°-123° C. (6.0 mmol, 2.16 g, 89%).

Sources & evidence

ORD record
ord-9c547876bf224c609d4783b7c8558753
Source dataset
uspto-grants-1995_10
Patent number
US05459151

Reaction notes

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