Water → 5-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione

HRID 2211819Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2211819
[N:1]([CH2:4][C:5]1[C:6](=[O:12])[NH:7][C:8](=[O:11])[NH:9][CH:10]=1)=[N+]=[N-].O.[H][H]>C(O)C.[Pd]>[NH2:1][CH2:4][C:5]1[C:6](=[O:12])[NH:7][C:8](=[O:11])[NH:9][CH:10]=1

Komponenten

6

Edukt 3

HCID 962WaterHCID 219630275-(azidomethyl)-2,4(1H,3H)-pyrimidinedioneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 152185025-(Aminomethyl)pyrimidine-2,4(1H,3H)-dioneAusbeute 86,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

The solution of 5-(azidomethyl)-2,4(1H,3H)-pyrimidinedione (0.275 g, 1.64 mmol) in ethanol: water (25:5 ml) was degassed with nitrogen, palladium on carbon (5%) was added, reaction was charged with hydrogen (55 PSI) and shaken for 2 h. The reaction was filtered and concentrated to give the 5-(aminomethyl)-2,4(1H,3H)-pyrimidinedione (0.20 g, 85%) as a solid. MS found: (M+H)+=142.

Aufarbeitung

  1. additionwas added
  2. customreaction
  3. filtrationThe reaction was filtered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-003b32cffb874c3296ecaabeed21de8b
Quelldatensatz
uspto-grants-2006_09
Patentnummer
US07101883B2

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