1,2-Dichloroethane → HCID 21957345, compound

HRID 2213367Notes

Reaction equation

HRID 2213367 reaction equation
C(OC(=O)[NH:7][CH2:8][CH:9]1[O:13][C:12](=[O:14])[N:11]([C:15]2[CH:20]=[CH:19][C:18]([N:21]3[CH:26]=[CH:25][C:24](=[O:27])[CH2:23][CH2:22]3)=[CH:17][CH:16]=2)[CH2:10]1)(C)(C)C.C(O)(C(F)(F)F)=O.[Cl:36]CCCl>>[ClH:36].[NH2:7][CH2:8][CH:9]1[O:13][C:12](=[O:14])[N:11]([C:15]2[CH:16]=[CH:17][C:18]([N:21]3[CH:22]=[CH:23][C:24](=[O:27])[CH2:25][CH2:26]3)=[CH:19][CH:20]=2)[CH2:10]1

Participants

4

Reactant 3

HCID 111,2-DichloroethaneHCID 6422Trifluoroacetic acidHCID 21051178HCID 21051178, compound

Product 1

HCID 21957345HCID 21957345, compound

Procedure

1-[4-(5-Aminomethyl-2-oxo-oxazolidin-3-yl)-phenyl]-2,3-dihydro-1H-pyridin-4-one hydrochloride is prepared from {3-[4-(4-oxo-3,4-dihydro-2H-pyridin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-carbamic acid tert-butyl ester following the method described for Example 3 using 25% TFA in DCE. MS (m/z): 288 [M−HCl+H]+.

Sources & evidence

ORD record
ord-7cdc8b92fa5c4831ac15fd0e027c976f
Source dataset
uspto-grants-2006_09
Patent number
US07105547B2

Reaction notes

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