反应详情

5-nitro-3-[1-(imidazol-4-yl)ethylidene]indolin-2-one (0.55 g, 2 mmol) was suspended in ethyl acetate (50 mL) and tin chloride (4.6 g, 20 mmol) was added. The resulting reaction mixture was heated overnight to 70° C. The reaction mixture was then cooled to ambient temperature and sodium bicarbonate solution was added. Extraction with ethyl acetate afforded 0.4 g of 5-amino-3-[1-(imidazol-4-yl)ethylidene]indolin-2-one.

1. customThe resulting reaction mixture
2. temperaturewas heated overnight to 70° C
3. extractionExtraction with ethyl acetate