Hydrochloric Acid → HCID 21948348, compound

HRID 2214825Notes

Reaction equation

HRID 2214825 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][C:22]3([NH:35][C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH2:27][CH2:26][N:25]([C:28]4[CH:33]=[CH:32][N:31]=[C:30]([CH3:34])[CH:29]=4)[CH2:24][CH2:23]3)[C:17](=[O:41])[CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][C:22]3([NH:35][C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH2:27][CH2:26][N:25]([C:28]4[CH:33]=[CH:32][N:31]=[C:30]([CH3:34])[CH:29]=4)[CH2:24][CH2:23]3)[C:17](=[O:41])[CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 219482954-(6-Chloronaphthalene-2-sulfonyl)-1-{[4-ethoxycarbonylamino-1-(2-methyl-4-pyridyl)-4-piperidinyl]methyl}-2-piperazinone

Product 1

HCID 21948348HCID 21948348, compoundYield 157.9%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

4-(6-Chloronaphthalene-2-sulfonyl)-1-{[4-ethoxycarbonylamino-1-(2-methyl-4-pyridyl)-4-piperidinyl]methyl}-2-piperazinone (215 mg) was suspended in ethyl acetate (10 ml), a 4N hydrochloric acid solution in ethyl acetate (0.3 ml) was added, and the resulting crystals were filtered off to obtain the title compound (180 mg) as colorless powders.

Workup

  1. filtrationthe resulting crystals were filtered off

Sources & evidence

ORD record
ord-7d3ea04a17704e1dbac33868bca9ad03
Source dataset
uspto-grants-2006_09
Patent number
US07109200B2

Reaction notes

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