反应详情

温度

80 °C

146.5 g (1.2 mol) of 4-hydroxybenzaldehyde are dissolved in DMF, and 20 g (0.12 mol) of potassium iodide, 134.6 g (1.2 mol) of potassium tert-butoxide and 170.2 g (1.8 mol) of 2-chloroethyl methyl ether are added. The reaction mixture is stirred at 80° C. for 16 h. For work-up, the reaction mixture is concentrated under reduced pressure. The residue is taken up in 1 l of ethyl acetate and extracted with 0.5 l of 1N aqueous sodium hydroxide solution. The ethyl acetate phase is dried using magnesium sulphate and concentrated under reduced pressure. The residue obtained after concentration is distilled under high vacuum (b.p.=100° C. at 0.45 mbar). This gives 184.2 g (85% of theory) of product.

1. concentrationFor work-up, the reaction mixture is concentrated under reduced pressure
2. extractionextracted with 0.5 l of 1N aqueous sodium hydroxide solution
3. dry with materialThe ethyl acetate phase is dried
4. concentrationconcentrated under reduced pressure
5. customThe residue obtained
6. concentrationafter concentration
7. distillationis distilled under high vacuum (b.p.=100° C. at 0.45 mbar)