Indoline → HCID 20766004, compound

HRID 2215102Notes

Reaction equation

HRID 2215102 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.Br[CH2:11][CH2:12][C:13]([O:15][CH3:16])=[O:14].C(=O)([O-])[O-].[K+].[K+]>>[CH3:16][O:15][C:13](=[O:14])[CH2:12][CH2:11][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 10328IndolineHCID 11430Potassium CarbonateHCID 76934Methyl 3-bromopropanoate

Product 1

HCID 20766004HCID 20766004, compound

Procedure

A solution of indoline (6.15 g), methyl 3-bromopropionate (13 g), potassium carbonate (21 g) in 150 mL of acetonitrie was refluxed fro 16 h. The reaction mixture was concentrated, mixed with 300 mL of ether. The mixed reaction solution was filtered, concentrated down to afford compound UUA (8 g). MS: 206 (M+1)+.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionmixed with 300 mL of ether
  3. customThe mixed reaction solution
  4. filtrationwas filtered
  5. concentrationconcentrated down
  6. customto afford compound UUA (8 g)

Sources & evidence

ORD record
ord-f2ec34b7b445413495b2cfb73538120c
Source dataset
uspto-grants-2006_09
Patent number
US07109222B2

Reaction notes

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